a tool for identifying drug-targetable redox-active disulphides

Beta-defensin 8

Intramolecular

Cysteine 38 and cysteine 52

A redox-regulated disulphide may form within Beta-defensin 8 between cysteines 38 and 52 (13 and 27 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

solution structure of the mouse defensin mbd-8

Structure deposition date

2000-07-12

Thiol separation (Å)

2

Half-sphere exposure sum ?

54

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

38

Residue number B

52

Peptide name

Beta-defensin 8

Ligandability

Cysteine 38 of Beta-defensin 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Beta-defensin 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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